This is the second of a three-part article looking at the area of interoperability and health information exchange (HIE) in the healthcare industry. In the first part, I attempted to clearly articulate the key challenges and barriers to adoption faced by those looking to engage in HIE. Part 2 will examine an architectural approach to address those challenges and discuss some technology enablers to realize a vision for high quality HIE. In the last part, I will share with you a success story from industry where this approach was put to the test.