Chelsea duo Yury Zhirkov and John Mikel Obi are both available after recovering from injuries.
The Blues’ only absentee is right-back Jose Bosingwa, who may require surgery to treat his knee problem.
Man Utd will again be without Rio Ferdinand, with boss Sir Alex Ferguson worried that the defender’s calf injury may be related to a lower back problem.
Nemanja Vidic (calf) should be fit to face the Blues, but Gary Neville sits out the match through suspension.
Doubtful: Berbatov (knee), Giggs (hip), Vidic (calf)
Injured: Ferdinand (calf/back), Hargreaves & Park (both knee), Wellbeck (knee) (BBC Sport)
This match up at Stamford Bridge is considered by many to be between the only two teams really battling for the title, which may well be a little unkind of the chasing pack, and therefore makes this crunch encounter all the more crucial.