Been a TWiT for months now and love Leo's shows. I think the author of this article is correct in that small is going to be the new big and Leo's template is an excellent one to copy. After watching and listening to Leo, I've even been tempted to start my own podcast.
Joss Whedon has already shown us what can be done by ignoring the Big Media concerns with Dr. Horrible. I don't know if it's made any money yet, but the fan base for that is incredible and I would be surprised if it wasn't in the black.